For decades, scientists believed a fertilized egg’s DNA began as a shapeless mass, only organizing itself once the embryo switched on its genes. But new research reveals that the genome is already carefully arranged in three dimensions long before that critical activation step, known as Zygotic Genome Activation. Using a powerful new method called Pico-C, researchers captured this hidden DNA architecture in unprecedented detail, showing that a complex scaffold is built early to control which genes will later turn on.
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